The New Probiotic Strain That Allows You To Eat Carbs Again, How GLP-1 Peptide Actually Works And Why It's Not Intended For Everyone

You might've heard me say it before: "The gut is the second brain." With over two decades of leadership in biotech, pharma, and academia, my guest on today's show, Colleen Cutliffe, is gut-deep :) in microbiome knowledge. Her path, spanning from the hallowed halls of Johns Hopkins University to groundbreaking initiatives at Pacific Biosciences and Elan Pharmaceuticals, showcases an unyielding curiosity about the mysteries of the human body. Now, as the driving force behind Pendulum Therapeutics, Colleen is charting new territories in the world of the microbiome. Akkermansia muciniphila, one of Pendulum's products, is a unique oval-shaped bacterium that thrives in the human gastrointestinal tract. This anaerobic microbe predominantly resides at the junction between oxygen-rich and oxygen-depleted zones of the intestines. Found in about 90% of healthy individuals, it constitutes 1% to 3% of your fecal microbiota. However, its prevalence can decrease with age or certain diseases. In today's chat, Colleen unravels the enigma of the gut-brain axis and its monumental influence on the microbiome's functionality. She sheds light on the role of natural agents like berberine, bitter melon extract, apple cider vinegar, and even pharmaceuticals like metformin in regulating blood sugar. With insights into the importance of Akkermansia muciniphila in GLP-1 production and the captivating genetic variations within the microbiome, this conversation promises a comprehensive look at gut health like never before. Full show notes: https://bengreenfieldlife.com/pendulumpodcast Episode Sponsors: JoyMode: Want to spice things up in the bedroom and boost your sexual performance? Visit usejoymode.com/GREENFIELD or enter GREENFIELD at checkout for 20% off your first order. Hiya: Get your kids the full-body nourishment they need to grow into healthy adults. Visit hiyahealth.com/BEN for 50% off your first order. Pendulum: Metabolic Daily is a powerful multi-strain probiotic that improves your metabolism, reduces sugar cravings, and breaks down carbs more efficiently. 20% off your first month with code GREENFIELD PendulumLife.com/Greenfield. Beam Minerals: If you want to up your mineral game, give Beam Minerals a try. Go to beamminerals.com and use code BEN at checkout for 20% off your order. FUM: Stopping is something we all put off because it’s hard, but switching to Füm is easy, enjoyable, and even fun. Visit tryfum.com/BEN and use code BEN for 10% off your order.See omnystudio.com/listener for privacy information.