Episode 1: Necrotizing Soft Tissue Infection
Critical Care Scenarios - En podcast af Critical Care Scenarios - Onsdage
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A troubling case of a painful finger. Resources References * Stevens DL, Bryant AE. Necrotizing Soft-Tissue Infections. N Engl J Med. 2017 Dec 7;377(23):2253-2265.* Bechar J, Sepehripour S, Hardwicke J, Filobbos G. Laboratory risk indicator for necrotising fasciitis (LRINEC) score for the assessment of early necrotising fasciitis: a systematic review of the literature. Ann R Coll Surg Engl. 2017 May;99(5):341-346. * A positive meta-analysis of IVIG for streptococcal NSTI: Parks T, Wilson C, Curtis N, Norrby-Teglund A, Sriskandan S. Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis. Clin Infect Dis. 2018 Oct 15;67(9):1434-1436.* … but then a negative RCT of its use for all comers. Madsen MB, Hjortrup PB, Hansen MB, et al. Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med. 2017 Nov;43(11):1585-1593* Weng TC, Chen CC, Toh HS, Tang HJ. Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice. J Microbiol Immunol Infect. 2011 Dec;44(6):418-23. Links * LRINEC score (MDCalc)* 5 Minute Sono (Jacob Avila on using ultrasound to diagnose NSTI)
