LAAOS 3

Star Update Podcast - Cardiology News Summaries - En podcast af ImagicaHealth

The goal of the trial was to evaluate surgical left atrial appendage occlusion compared with no occlusion among patients with atrial fibrillation undergoing open-heart surgery. In this trial, 4770 patients on anticoagulation therapy for over 3 years with atrial fibrillation with CHA2DS2-VASc ≥2, were randomized to undergo open-heart surgery with or without left atrial appendage occlusion In results: The primary outcome of ischemic stroke or systemic embolism after 3.8 years occurred in 4.8% of the occlusion group compared with 7.0% of the no occlusion group with a significance of 0.001 In the Secondary outcomes, the event of Ischemic stroke was also significantly lesser to the non-occlusion arm. Among patients with atrial fibrillation undergoing cardiac surgery, left atrial appendage occlusion was found to be superior to no occlusion. More benefit was observed when the results were landmarked at 30 days versus <30 days. Major bleeding was similar between the treatment groups. Thus to conclude the benefit of surgical left atrial appendage occlusion appeared to be additive to anticoagulation therapy; therefore, this trial does not support surgical left atrial appendage occlusion as a replacement to anticoagulation therapy. Disclaimer: Lupin makes no representation or warranty of any kind, expressed or implied, regarding the accuracy, adequacy, validity, reliability, availability or completeness of any scientific information shared by the HCP on the ­­­STAR UPDATE podcast. You should not allow the contents of this to substitute for your own medical judgment, which you should exercise in evaluating the information on this website.

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