PREVIEW Aliquot #6: Genetic and lifestyle risk factors for Alzheimer's disease

The single most important genetic risk factor for Alzheimer's disease is a variant of apolipoprotein E, or APOE for short, a lipoprotein produced in the liver and brain. Roughly a quarter of all people living in the US – about 75 million people – carry a genetic variant of APOE called APOE4. Having APOE4 is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.    But having APOE4 doesn't mean that Alzheimer's disease is inevitable. In fact, lifestyle behaviors can modulate risk for the disease, too, especially sleep, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk. Understanding our genetic risks and addressing lifestyle behaviors – especially our sleep patterns – can influence whether a person eventually develops Alzheimer's disease. These Aliquot segments feature Dr. Dale Bredesen, a professor of neurology, and Dr. Matthew Walker, a professor of neuroscience and psychology. (00:00) Introduction (02:37) ApoE4 increases Alzheimer’s disease risk, but healthy habits can reduce risk (Dale Bredesen discussion) (05:20) People who are ApoE4+ have 2x the risk of having sleep apnea (Matthew Walker segments) (12:03) Glial cells are the sewage system for the brain You can see the original full interview with Dr. Bredesen   You can see the original full interview with Dr. Walker   Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more.   Learn more and sign up at: www.foundmyfitness.com/crowdsponsor

Om Podcasten

This is the Aliquot Preview - a sneak peek into FoundMyFitness’s members-only podcast: The Aliquot. Learn more about The Aliquot at foundmyfitness.com/aliquot. Every month we release one free preview episode here so you can sample one of the many FoundMyFitness Premium Membership benefits. So what is an aliquot? An aliquot is a sample taken from a larger whole, that captures the essence of the entirety. FoundMyFitness Aliquots are short, members-only podcasts focused on single topics, curated and remixed to surface our richest content on the most popular topics like diet and nutrition, health span and life extension, exercise, fasting, ketosis, sauna and cold exposure, sleep and depression. Some episodes are edited excerpts, highlights, and informative moments taken from full interviews in the FoundMyFitness podcast (with a little more context from Dr Rhonda Patrick!) Other episodes are mash-ups and highlights from our regular Q&As with members. Become a FoundMyFitness Premium member to get access to weekly Aliquots, biweekly Science Digest emails, and monthly Q&As with Rhonda. Learn more at foundmyfitness.com/crowdsponsor.