Ep. 145: “Cardiac Organoids” Featuring Dr. James Hudson

Guest: Dr. James Hudson is Group Leader of the Organoid Research Laboratory at the QIMR Berghofer Medical Research Institute in Brisbane, Australia, whose research is focused on developing state-of-the-art bioengineering approaches for human 3D organoids to use for studying cardiac biology and discovering new heart disease therapeutics. Featured Products and Resources: STEMdiff™ Cardiomyocyte Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability Resources and Links Stimulating Hair Growth - Investigators have demonstrated that quiescent hair follicles can be stimulated to grow by small molecules that activate autophagy. Organoid Model of Fibrotic Lung Disease - Researchers used ESC-derived 3D organoids to model fibrotic lung disease, and identified a possible pathogenic mechanism. Antibody Conditioning for HSC Transplants - A transplant of mismatched HSCs without immune suppression by chemotherapy or radiation was successful in mice by performing a conditioning treatment with six antibodies. Improving Pancreatic Islet Transplantation - Researchers have identified a protein that improves revascularization of pancreatic islet grafts, and is a potential target for enhancing transplant outcomes in type 1 diabetes. Reprogramming Scar Tissue into Heart Muscle - For the first time, scientists have developed a stable, reproducible, and minimilistic platform to reprogram human fibroblast cells into cardiomyocytes. Photo Reference: Courtesy of Dr. James Hudson #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; }